[转帖]最早的H7N9病毒记录：1988年来自美国卫生部

美国转基因

[转帖]最早的H7N9病毒记录：1988年来自美国卫生部

    最早的H7N9病毒记录：1988年，来自美国卫生部(2013-04-23 02:06:41)   

    在网上查到关于H7N9禽流感最早的记录，来自美国卫生部,美国国家生物技术信息中心；时间：1988年，地点：美国明尼苏达州，感染动物：火鸡。科学杂志2006年某刊作为索引文献的15个作者中，6人姓名看起来是中国人。病毒的基因序列也列在文章中。网址如下：

    http://www.ncbi.nlm.nih.gov/nuccore/CY014787.1Influenza A virus (A/turkey/Minnesota/1/1988(H7N9)) segment 7, complete sequence

    GenBank: CY014787.1

    FASTA Graphics

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    •Features

    •Sequence

    LOCUS       CY014787                1027 bp    cRNA    linear   VRL 21-SEP-2006

    DEFINITION  Influenza A virus (A/turkey/Minnesota/1/1988(H7N9)) segment 7,

    complete sequence.

    ACCESSION   CY014787

    VERSION     CY014787.1  GI:115278574

    KEYWORDS    .

    SOURCE      Influenza A virus (A/turkey/Minnesota/1/1988(H7N9))

    ORGANISM  Influenza A virus (A/turkey/Minnesota/1/1988(H7N9))

    Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;

    Influenzavirus A.

    REFERENCE   1  (bases 1 to 1027)

    AUTHORS   Obenauer,J.C., Denson,J., Mehta,P.K., Su,X., Mukatira,S.,

    Finkelstein,D.B., Xu,X., Wang,J., Ma,J., Fan,Y., Rakestraw,K.M.,

    Webster,R.G., Hoffmann,E., Krauss,S., Zheng,J., Zhang,Z. and

    Naeve,C.W.

    TITLE     Large-scale sequence analysis of avian influenza isolates

    JOURNAL   Science 311 (5767), 1576-1580 (2006)

    PUBMED   16439620

    REFERENCE   2  (bases 1 to 1027)

    AUTHORS   Obenauer,J.C., Denson,J., Mehta,P.K., Su,X., Mukatira,S.,

    Finkelstein,D.B., Xu,X., Wang,J., Ma,J., Fan,Y., Rakestraw,K.M.,

    Webster,R.G., Hoffmann,E., Krauss,S., Zheng,J., Zhang,Z. and

    Naeve,C.W.

    TITLE     Direct Submission

    JOURNAL   Submitted (13-SEP-2006) Hartwell Center for Bioinformatics &

    Biotechnology, St. Jude Children""""s Research Hospital, 332 North

    Lauderdale Str., Memphis, TN 38105, USA

    402490"

    /segment="7"

    /country="USA: Minnesota"

    /collection_date="13-Jul-1988"

    primer_bind     1..15

    /note="PCR amplification primer sequence"

    gene            26..1007

    /gene="M2"

    CDS             join(26..51,740..1007)

    /gene="M2"

    /codon_start=1

    /product="matrix protein 2"

    /protein_id="ABI84696.1"

    /db_xref="GI:115278576"

    /translation="MSLLTEVETPTRNGWECKCSDSSDPLVIAASIIGILHLILWILD

    RLFFKCIYRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE"

    gene            26..784

    /gene="M1"

    CDS             26..784

    /gene="M1"

    /codon_start=1

    /product="matrix protein 1"

    /protein_id="ABI84695.1"

    /db_xref="GI:115278575"

    /translation="MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALME

    WLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRK

    LKREITFHGAKeva1SYSTGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHR

    SHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRT

    IGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK"

    primer_bind     complement(1007..1027)

    /note="PCR amplification primer sequence"

    ORIGIN      

    1 agcaaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cgtacgttct

    61 ctctatcgtc ccgtcaggcc ccctcaaagc cgagatcgcg cagagacttg aagatgtctt

    121 tgcagggaag aacaccgatc ttgaggcact catggagtgg ctaaagacaa gaccaatcct

    181 gtcacctctg accaagggga ttttaggatt tgtgtttacg ctcaccgtgc ccagtgagcg

    241 aggactgcag cgtagacgct ttgtccaaaa tgcccttaat gggaatgggg atccaaacaa

    301 catggacaga gcagtcaaac tatacaggaa actaaaaagg gaaataacat tccatggggc

    361 aaaagaagta gcactcagtt attcaactgg tgcacttgcc agttgcatgg gcctcatata

    421 caacagaatg gggactgtga ccaccgaagt ggcatttggc ctggtgtgcg ccacatgtga

    481 gcagattgct gattcccagc atcggtctca cagacaaatg gtgacaacaa ccaacccact

    541 aatcagacat gagaacagaa tggtactagc cagtactacg gctaaagcca tggagcaaat

    601 ggcaggatca agtgagcaag cagcagaggc tatggaggtt gctagtcagg ctaggcaaat

    661 ggtgcaggca atgaggacca ttggaactca tcctagctcc agtgctggtc taaaagatga

    721 tcttcttgaa aatttgcagg cctaccagaa acggatggga gtgcaaatgc agcgattcaa

    781 gtgatcctct cgttattgcc gcaagtatca ttgggatctt gcacttgata ttgtggattc

    841 ttgatcgtct tttcttcaaa tgcatttatc gtcgccttaa atacggtttg aaaagagggc

    901 cttctacgga aggagtgcct gagtctatga gggaagaata ccggcaggaa cagcagagtg

    961 ctgtggatgt tgacgatggt cattttgtca acatagagct ggagtaaaaa actaccttgt

    1021 ttctact